Dietary supplementation with BioCell Collagen® significantly reduced facial lines and wrinkles, crow’s feet lines/wrinkles, increased skin elasticity and cutaneous collagen content, and decreased skin dryness compared to placebo.

The intervention consisted of twice daily 500mg oral administration of BioCell Collagen®, a novel hydrolyzed chicken sternal cartilage extract dietary ingredient composed of a naturally-occurring matrix of collagen type-II peptides (≥300 mg), chondroitin sulfate (≥100 mg), and hyaluronic acid (≥50 mg). 

For the 113 participants completing the study, BioCell Collagen® supplementation compared to a placebo resulted in:
• Significantly reduced facial lines and wrinkles (P = .019) and crow’s feet lines and wrinkles (P = .05)
• Increased skin elasticity (P = .008) and cutaneous collagen content (P < .001) by 12%
• Improved indicators associated with a more youthful skin appearance based on visual grading and wrinkle width (P = .046)
• Decreased skin dryness and erythema.
• No difference existed between the supplement and the placebo for skin surface water content or retention. 

The supplement was well tolerated, with no reported adverse reactions. 

The latest study validates an earlier pilot study that demonstrated similar results- Schwartz SR, Park J. Ingestion of BioCell Collagen®, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs.