Oregon State University and US Department of Agriculture researchers say they have significantly expanded the understanding of the hop genome, a development with important implications for the brewing industry and scientists who study the potential medical benefits of hops. The findings are outlined in a paper just published in the journal The Plant Genome.

“This research has the unique ability to impact several different fields,” said David Hendrix, an associate professor in the Department of Biochemistry and Biophysics and the School of Electrical Engineering and Computer Science at Oregon State.

“If you’re talking to beer drinkers, they will be excited about the brewing side. If you are talking to the medical field, they are going to be excited about the pharmaceutical potential.”

Demand for hops has surged in recent years as the craft beer industry has grown, fuelled by beers, such as Indian Pale Ales, that are brewed with a lot of hops. This has led brewers to seek out new varieties of hops. With a better understanding of the hop genome, scientists will have an easier time developing new varieties, which may have qualities such as different flavour profiles or resistance to diseases that infect and damage hop plants.

“This really opens the door wide for breeding hops at the molecular level,” co-author John Henning from the US Department of Agriculture said. “We now have a much better understanding of how traits are being controlled and what genes are involved.”

The researchers sequenced the genome of Cascade, a hop cultivar developed by USDA Agricultural Research Service in the 1960s and credited with helping to launch the craft beer movement. It is the second most widely grown hop variety in the United States today.

The US is the top hop producing country in the world and Washington, Oregon and Idaho account for nearly all the hop acreage in the United States. In 2019, production of hops in the United States was worth more than $600 million.

Other scientists have attempted to sequence the hop genome, but they have had limited success because it is large – similar in size to the human genome – and complex, Hendrix said. The current research was made possible in part by new genome sequencing and assembly technology developed by Pacific Biosciences of California.

“The previous genomes were basically broken up,” Hendrix said. “They were sequencing a lot of the genes, but they were isolated islands of the genome and they were not really getting the full context of what was going on in those islands. We were able to reveal a more complete and continuous genomic sequence.”