Related Searches: Tea Vitamin Nutrients Ingredients paper cup packing

Food & Health Ingredients
Health & Nutrition
Processing & Packaging
Starch & Starch Derivatives

Study investigates hydroxytyrosol supplementation in breast cancer

nutraceuticalbusinessreview 2022-04-22
Share       
Tag:

A recently published triple-blind randomised study found that Euromed’s olive fruit extract Mediteanox, standardised for hydroxytyrosol, shows chemomodulatory effects when combined with chemotherapy in breast cancer patients.

Hydroxytyrosol is an antioxidant polyphenol with anti-inflammatory potential that occurs naturally in olives and extra virgin olive oil. It is derived from the polyphenol oleuropein by hydrolysis during olive maturation and olive oil storage.

Most cancer-treating drugs are not selecive against tumour cells and also affect normal cells, leading to several adverse reactions such as the production of free radicals.

Therefore, the researchers who conducted this study aimed to clarify whether the antioxidant hydroxytyrosol has a chemomodulatory effect when combined with the chemotherapeutic drugs epirubicin and cyclophosphamide (followed by taxane cytostatics) in breast cancer patients.

They established two groups: 20 women in the treatment group received a single dose of Mediteanox (15 mg of hydroxytyrosol) per day in the form of hard capsules, and 20 women in the control group received a placebo.

Plasma level changes of matrix metalloproteinase 9 (MMP-9) and a tissue inhibitor of metalloproteinase 1 (TIMP-1) were studied throughout the chemotherapy.

Both molecules are involved in cell proliferation, apoptosis, neoangiogenesis and metastasis in breast cancer patients. The results showed that the plasma levels of TIMP-1 in patients receiving hydroxytyrosol were significantly lower than those levels found in the control group after the treatment.

The strong antioxidant potential of hydroxytyrosol may play an important role in explaining these positive effects.

According to EFSA, olive oil polyphenols such as hydroxytyrosol contribute to the protection of blood lipids from oxidative stress. Further studies are needed to clarify the exact mode of action by which hydroxytyrosol leads to a decrease in TIMP-1 levels.

However, the selected combination of dietary supplementation with hydroxytyrosol and chemotherapy is a promising starting point for further clinical research on hydroxytyrosol as an adjunct to pharmaceutical therapy for breast cancer.

E-newsletter

Subscribe to our e-newsletter for the latest food ingredients news and trends.

Tags

Recommended Products

DZP(Q)500/2SB Vacuum Packager

DZP(Q)500/2SB Vacuum Packager

Genlai Fructose

Genlai Fructose

Edible Halal Fish Gelatin 200bloom

Edible Halal Fish Gelatin 200bloom

Yusweet C xylitol

Yusweet C xylitol

Gas Proportioning

Gas Proportioning

Valve positioner IL TOP

Valve positioner IL TOP

Top

SJGLE B2B Website : 中文版 | ChineseCustomer Service: 86-400 610 1188-3 ( Mon-Fri 9: 00-18: 00 BJT)

About Us|Contact Us|Privacy Policy|Intellectual Property Statement

Copyright 2006-2023 Shanghai Sinoexpo Informa Markets International Exhibition Co Ltd (All Rights Reserved). ICP 05034851-121