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Hawthorn Leaf Extract and Nervonic acid of Qingchun Kangyuan

en-cphi.cn 2018-01-11
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I. Hawthorn Leaf Extract

 

Hawthorn leaf extract is a natural extract with broad effects and few adverse reactions. The Flavonoids in hawthorn leaves have effects such as reducing blood pressure, increasing coronary blood flow, lowering lipid, lowering triglyceride and cholesterol, bearing hypoxia, inhibiting or scavenging oxygen free radicals, resisting to lipid peroxidation, improving hepatic microcirculation, resisting to inflammatory injuries, and having a tonic effect on the heart, with great clinical value in cardio-cerebral vascular system. The extract is applicable to pharmaceutical, health product, daily necessities, and cosmetics fields, etc.

Hawthorn leaf extract is processed and made from the dried leaves of the rosaceous plant large-fruited Chinese hawthorns or hawthorns. With the raw materials from the quality hawthorn planting base in Shanxi, our company has conducted years of systematic quality analysis and tracking as well as laboratory process validation of the raw material resources of the origin, of which the quality can be controlled. Selecting the best collection period according to the experiment and test results can make the best of resources, guarantee the yield and quality, and increase the utilization value.

Currently, we use the macroporous adsorption resin of Sunresin Inc. Using the macroporous resin adsorption and separation technology for the active ingredients can effectively raise the product yield and reduce costs, to provide effective support for the competition of the product. Our macroporous resin is selected after test of more than ten kinds of macroporous resin of the same model, features good selectivity, high yield, no harmful residues, high product content, and stable quality, and has distinct competitive edges.

Process flow of hawthorn leaf extract

Our hawthorn leaf extract is complete in specifications, and the monthly production of various specifications can reach 3t. We have a perfect GMP management system, and a professional technology and production management team with more than 10 years of rich experience in pharmaceutical production quality. The specific product specifications are as follows:

Product name

Specification

Detection method

Nature

Hawthorn leaf extract

(HPLC characteristic peaks and specific chromatograms of all series of products comply with requirements of the Chinese Pharmacopoeia 2015 Edition) Main ingredients: Flavonoids

1. Vitriol 2-o mouse liglucoside

2. St Johns wort glycosides

 

Total flavonoids 20.0%

UV

Yellowish brown powder

Total flavonoids 40.0%

UV

Yellowish brown powder

Total flavonoids 80.0%

UV

Brownish red powder

Total flavonoids 95.0%

UV

Brownish red powder

Total flavonoids 20.0%, Vitexin-2-O-rhamnoside 2.0%, hyperoside 0.1%

HPLC

Yellowish brown powder

Total flavonoids 40.0%, Vitexin-2-O-rhamnoside 5.0%, hyperoside 0.2%

HPLC

Yellowish brown powder

Total flavonoids 80.0%, Vitexin-2-O-rhamnoside 10.0%, hyperoside 0.4%

HPLC

Brown powder

Hawthorn leaf total flavonoids 90.0%, Vitexin-2-O-rhamnoside 15.0%, hyperoside 0.6%

HPLC

Brown powder

II. Cis-15-Tetracosenoic Acid (Nervonic acid)

Nervonic acid

Cis-15-Tetracosenoic acid (nervonic acid) CAS#: 506-37-6

                     

Source:         Acer truncatum bunge seed oil or rapeseed oil

Nature:         White flaky crystal

Specification: ≥90% nervonic acid

Efficacy: With high content in nerve tissues and brain tissues, nervonic acid helps the brain function efficiently, promotes brain development, and repairs damaged nerve endings.

Application recommendation: Pharmaceutical, health product, and food fields, etc.

Cis-15-Tetracosenoic acid is intermediate (Z)-15-Tetracosenoic acid of natural products that is obtained through enrichment and purification with natural oils such as Acer truncatum bunge seed oil and rapeseed oil rich in (Z)-15-Tetracosenoic acid as the raw material. This product is intermediate of natural products, thus can be used in food and pharmaceutical fields; it is mainly used for the synthesis of muscone, cyclopentadecanone, exaltolide, and pheromone, soluble in n-hexane, petroleum ether, acetone, and alcohol, insoluble in water; it is nonflammable, non-volatile, and non-corrosive.

Product Technical Requirements

Item

Index

Appearance

White crystalline powder

(Z)-15-Tetracosenoic /%               ≥

90.0

Peroxide /%                              ≤

10

Unsaponifiable matter /%                     ≤

1

Melting point /°C         

39.5~42.5

Acid value /mgKOH/g                     ≤

160

Moisture /%                   ≤

1.5

Residue on ignition /%           ≤

0.1

Heavy metal (Pb) /%             ≤

0.002

Recommended serving size: ≤300mg/d

Production process:

SGS test report

Report of product sent to JFRL for test by Japanese customer Iskra

 

CNNM

HNNM

III. Factory Show

Office building

Area II, Extraction Workshop

Workshop Clean Area

Atomic Absorption Spectrometer

Gas Chromatograph

Liquid Chromatograph

Qingchun Kangyuan is committed to the research, development, application, production and sales of TCM and natural product components. The company covers an area of 67,000m² and is capable of processing 3,000t raw materials every year, wherin, its hawthorn leaf extract and Cis-15-Tetracosenoic acid are leading in the industry. It can provide high-quality natural plant extract raw materials and professional services to Chinese and foreign herbal medicine companies, health product factories, and beverage and cosmetics manufacturers.

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